To evaluate a topical HIV prevention product using a nonhuman primate, repeat low dose model to define activity and toxicity of an intravaginal ring product.

To facilitate the formation of a HIV Trials Network to advance research, therapy and prevention. If the interventions in the clinical trials are determined safe and effective, they will add to the options available to prevent and control these diseases of global significance.

To strengthen vaccine-preventable disease surveillance platforms to maximize their capacity to measure burden of disease and to monitor the impact of vaccines. Activities include improving immunization data quality; evaluating impact and implementation of vaccines (including oral cholera, rubella, and HPV); improving the quality and planning of measles and rubella campaigns; and strengthening surveillance for vaccine preventable diseases (meningitis, diphtheria and pertussis, intussusception).

To explore the feasibility of human papillomavirus vaccine impact in a low resource setting.

To promote safety and wellness among U.S. travelers through the collection and dissemination of up-to-date and accurate scientific information.

To facilitate formation of a Clinical Trials Unit for HIV/AIDS and tuberculosis research to advance therapy and prevention. If the interventions in the clinical trials are determined safe and effective, they will add to the options available to prevent and control these diseases of global significance.

To provide substance use and HIV prevention education, access to health services, safe and supportive environments and monitoring and evaluation for high-risk communities in Kentucky, Ohio and Indiana.

To explore the effectiveness of opt-out chlamydia screening via electronic health record prompt and to increase the percentage of women under the age of 25 who are screened for chlamydia at clinical encounters.

To reduce potentially deadly bloodstream infections in hemodialysis outpatients by targeting patients, healthcare providers and caregivers using evidence-based communications strategies with prevention messages.

To gain a comprehensive understanding of antibiotic use in inpatient and outpatient healthcare settings in the United States.